Platelet-Rich Plasma-Contained Drug Delivery Systems to Treat Orthopedic Injuries
Platelet-rich plasma (PRP), an autologous biocomponent, has been clinically applied in tissue regeneration and repair, yet it faces challenges such as unclear mechanisms, side effects, and uncontrollable release. This review provides evidence for further clinical research on PRP and its associated drug delivery strategies in orthopedics.
Analysis of risk factors affecting wound infection after open ankle fracture surgery
This study aimed to analyze the incidence and risk factors associated with surgical site infection (SSI) following open reduction and internal fixation (ORIF) for ankle fractures.
Understanding the differences between mobility and flexibility
Mobility and flexibility are related but distinct. Improving flexibility and mobility may improve a person’s athletic performance and range of motion, and help to reduce the risk of injuries.
Synovial fluid protein levels may predict osteochondral allograft transplantation outcomes
Elevated levels of synovial fluid proteins may be associated with poor outcomes after osteochondral allograft transplantation. Synovial fluid protein levels may be used as a biomarker to predict outcomes.
Corticosteroids Versus Platelet-Rich Plasma Injections for Knee Osteoarthritis: Where is there More Evidence? A Systematic Review of 60 Years of Literature
PRP injections for knee OA have been documented in more studies and in larger patient numbers compared with CS injections. The higher number of high-level trials for PRP, combined with the lower safety and efficacy documented for CS by previous meta-analyses directly comparing the two products, strongly suggests reconsidering current guidelines that favor CS, highlighting PRP’s body of evidence and the potential role in the effective and safe treatment of knee OA.
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