Stem Cells in Orthopedic Rheumatology: Where Clinical Signals Are Strongest
Stem-cell therapies in orthopedic rheumatology offer dual promise: immunomodulation and tissue repair. This editorial reviews 2023-2025 evidence across key rheumatic diseases, identifying where clinical signals are strongest. Mesenchymal stromal/stem cells (MSCs) show encouraging immunologic and symptomatic benefits in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), particularly lupus nephritis, with acceptable short-term safety. However, trial heterogeneity in MSC source, dose, and manufacturing limits reproducibility.
Source: ResearchGate
Fear of Reinjury Is Associated With Worse Physical Function Measured by PROMIS Following Minimally Invasive Achilles Rupture Repair
Prior literature suggests that patients suffering from fear of reinjury (FORI) following Achilles rupture may fail to return to sport and report worse Achilles Tendon Total Rupture Scores (ATRS); however, this prior study included patients who underwent both surgical and non-surgical management. This study therefore aims to determine whether self-reported fear (srFORI) is associated with worse outcomes as measured by validated Patient-Reported Outcomes Measurement Information System (PROMIS) measures of physical function (PF) and pain interference (PI) and ATRS following operative Achilles repair specifically.
Source: Foot & Ankle Orthopaedics
11 Causes of Swollen Ankles and Feet
Swollen ankles and feet can result from various conditions, ranging from minor issues like prolonged standing to serious health problems such as heart disease. Learn when to seek medical attention and how to manage the swelling effectively.
Source: Verywell Health
6 Physical Therapy Exercises for Achilles Tendonitis
Stretching and strengthening the calf muscles with exercises can relieve Achilles tendonitis.Use heavy weight-bearing exercises as part of your recovery only with the guidance of a physical therapist.
Source: Verywell Health
Application of Stem Cells in Degenerative Orthopedic Diseases
Degenerative orthopedic diseases, traditionally viewed as inevitable “wear-and-tear” processes, are now being reimagined as dynamic failures of tissue homeostasis orchestrated by a complex interplay of chronic inflammation and metabolic exhaustion.
Source: Frontiers
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